• HPE ProLiant DL385 Gen10 Plus – 2U Dual-Socket AMD EPYC with 4 TB DDR4 & PCIe Gen4

    Keywords

    HPE ProLiant DL385 Gen10 Plus,#HPE ProLiant DL385 Gen10 Plus, AMD EPYC 7000,#AMD EPYC 7000, DDR4 3200 MHz,#DDR4 3200 MHz, PCIe Gen4,#PCIe Gen4, OCP 3.0,#OCP 3.0, NVMe bays,#NVMe bays, HPE iLO 5,#HPE iLO 5, HPE InfoSight,#HPE InfoSight

    Description

    The HPE ProLiant DL385 Gen10 Plus leverages the 2nd-Gen AMD EPYC™ 7000 processors to deliver up to 2× the core density of its predecessor, with support for 8, 16, 24, 32, 48, 64, or 128 cores per socket, accelerating virtualization and HPC workloads

    Equipped with 32 DDR4 SmartMemory slots running at 3200 MT/s, it scales to 4 TB of ECC memory, enabling in-memory analytics and large-scale databases without compromise.

    The server’s modular design offers up to 28 SFF, 20 LFF, or 16 front-accessible NVMe bays, complemented by embedded M.2 RAID boot support, allowing tiered storage architectures within a 2 U footprint(Hewlett Packard Enterprise).

    Integrated HPE iLO 5 and cloud-AI monitoring via HPE InfoSight provide continuous health insights, automated firmware validation, and proactive issue prevention to maximize uptime across hybrid-cloud environments.

    Key Features

    • 2nd-Gen AMD EPYC™ 7000 CPUs: Up to 128 cores, 256 MB L3 cache, 3.2 GHz max speed

    • Large DDR4 Capacity: 32 DIMMs @ 3200 MT/s, up to 4 TB ECC memory

    • Modular Storage Bays: Up to 28 SFF, 20 LFF, or 16 NVMe bays; optional rear drives; embedded M.2 RAID boot( Hewlett Packard Enterprise)

    • High-Speed I/O: 8 PCIe Gen 4 slots; choice of OCP 3.0 or stand-up PCIe adapters for 10/25/100 GbE or NVMe controllers

    • HPE iLO 5: Remote management, RESTful Redfish, SNMP, IPMI, and KVM-over-IP; automated alerts & firmware validation

    • Silicon Root of Trust: End-to-end firmware integrity, run-time validation, and automatic recovery

    • HPE InfoSight: Cloud-based AI for predictive analytics and proactive issue resolution

    • Flexible Power & Cooling: Hot-plug redundant fans; platinum-efficiency PSUs; optional liquid-cool heat sinks

    Configuration

    Component Specification
    Model HPE ProLiant DL385 Gen10 Plus
    Form Factor 2 U rack server
    Processors 2× AMD EPYC 7000 Series (2nd Gen), 8–128 cores/socket, up to 3.2 GHz
    Memory 32× DDR4 DIMM slots @ 3200 MT/s; up to 4 TB ECC
    Storage Bays Up to 28× SFF or 20× LFF or 16× NVMe front; optional rear 4× LFF/SFF; embedded 2× M.2 RAID boot
    Expansion Slots 8× PCIe Gen 4; choice of OCP 3.0 or stand-up PCIe adapters
    Network Options 10/25/100 GbE or NVMe-oF via OCP or PCIe
    Management HPE iLO 5; Intelligent Provisioning; OneView integration; InfoSight analytics
    Security Silicon Root of Trust; AMD Secure Processor; TPM 2.0; Secure Boot
    Power & Cooling Redundant hot-plug PSUs; N+1 fans; optional liquid cooling
    Warranty 3 yr parts, 3 yr labor, 3 yr onsite NBD support

    Compatibility

    • Operating Systems: Windows Server; RHEL; SLES; Ubuntu; CentOS; Debian 

    • Virtualization: VMware ESXi; Microsoft Hyper-V; KVM 

    • Hybrid Cloud: Integrates with HPE OneView, GreenLake, and Synergy composability

    Usage Scenarios

    1. Virtualization & Private Cloud
      High core count and memory capacity support dense VM consolidation and hybrid-cloud workloads.

    2. HPC & AI
      AMD EPYC compute and NVMe tiers accelerate simulation, modeling, and AI inference at scale.

    3. Database & In-Memory Analytics
      Large DDR4 footprint and PCIe Gen4 I/O deliver low-latency transaction processing.

    4. Software-Defined Storage
      Combine SAS, SATA, and NVMe drives under Smart Array RAID for scalable SDS architectures.

    Frequently Asked Questions

    Q1: What core counts and memory speeds are supported?
    A1: Supports 8–128 cores per socket (2nd-Gen AMD EPYC™) and 32× DDR4 DIMMs at up to 3200 MT/s, for up to 4 TB ECC memory.

    Q2: Which storage form factors can I choose?
    A2: Up to 28 SFF, 20 LFF, or 16 NVMe front bays; optional rear drives; embedded hot-pluggable M.2 RAID boot(Hewlett Packard Enterprise).

    Q3: How do I manage and automate updates?
    A3: HPE iLO 5 offers RESTful Redfish, SNMP, IPMI, and KVM-over-IP, plus integration with HPE OneView and InfoSight for full lifecycle automation.

    Q4: What security features are built in?
    A4: Silicon Root of Trust anchors firmware, AMD Secure Processor manages secure boot and memory encryption, and runtime validation with automated recovery ensures a zero-trust posture.

    Q5: Can I add GPUs or liquid cooling?
    A5: Yes—supports up to 8 single-width or 3 double-width GPUs, and optional closed-loop liquid cooling modules for high-TDP processors.

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